It has been estimated that 6.3 million Americans suffer from heart failure. Heart failure is a heterogeneous clinical syndrome stemming from cardiac overload and injury that leads to considerable morbidity and mortality.
Coronaviruses are enveloped, positive-sense single stranded viruses ((+)ssRNA virus) belonging to the family Coronaviridae. Most coronaviruses have 8-10 open reading frames (ORFs). ORF1a and ORF1b are translated into polyprotein 1a (pp1a) and
Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum lipids can